In 1994, Bindley Western Industries (BWI) created Priority Healthcare Corporation (PHC) to provide pharmaceutical distribution services to the non-acute market. In 1997, BWI announced the initial public offering of PHC with the company's stock trading on the NASDAQ Stock Market under the symbol PHCC. In April of 1999, PHC purchased Pharmacy Plus, Ltd., a specialty pharmacy that provided injectable biopharmaceuticals to patients via overnight delivery.

In October 2005, industry-leading pharmacy benefit manager (PBM) Express Scripts completed the acquisition of Priority Healthcare Corporation and combined it with their existing specialty offering to create one of the largest specialty pharmaceutical dispensing and distribution companies in the United States.

On April 2, 2012, Express Scripts and Medco completed their merger and became a combined organization with more than 200 facilities with over 33,000 employees located on three continents.