Did You Know? Menetrier Disease is more common in men
Menetrier Disease is Rare and the Average Age at Diagnosis is 55
Menetrier Disease goes by many names – Giant Hypertropic Gastritis, Protein Losing Gastroenteropathy, Giant Hypertrophic Gastropathy, but what is it? Menetrier Disease is a gastrointestinal (GI) condition characterized by an overgrowth of the mucous cells in the lining of the stomach. Learn more about Menetrier Disease, symptoms, diagnosis and treatment in the following summary.
01 | What is Menetrier Disease?
In a normal stomach, mucous cells in the ridges of the stomach lining, or rugae, release protein-containing mucus. In Menetrier Disease, the rugae enlarge and form giant folds in the stomach lining. Too much mucus is released causing proteins to leak from the blood into the stomach.
Although the exact cause of Menetrier Disease is unknown, studies have found that patients have abnormally high levels of TGF-α. Studies have also found a link between Menetrier Disease and H. pylori infection, as well as cytomegalovirus (CMV).
02 | Signs and Symptoms
While some individuals may not exhibit any symptoms, most patients complain of pain in the upper middle part of the abdomen (epigastric pain). Other symptoms include:
03 | Diagnosis
A diagnosis of Menetrier Disease is confirmed through a CT scan, upper GI endoscopy and a biopsy of the stomach tissue. These tests, along with a physical exam and medical and family history will help determine a positive diagnosis.
04 | Treatment
Treatment will likely include a combination of therapies, including the following:
For more information on Menetrier Disease, please visit: https://rarediseases.org/rare-diseases/menetrier-disease/